Autori: Cassidy CM, Zucca FA, Girgis RR, Baker SC, Weinstein JJ, Sharp ME, Bellei C, Valmadre A, Vanegas N, Kegeles LS, Brucato G, Kang UJ, Sulzer D, Zecca L, Abi-Dargham A, Horga G.
Significato: Ulteriore validazione della risonanza magnetica come mezzo diagnostico non invasivo e non radioattivo per la valutazione quantitativa della funzione dopaminergica, che è compromessa nella malattia di Parkinson. La risonanza si presta ad uso ripetuto, per cui potrà essere usato per monitorare la funzione dopaminergica nel corso di studi su terapie con lo scopo di rallentare la progressione della malattia. Si presta anche allo screening di soggetti a rischio con lo scopo di effettuare una diagnosi precoce e per la messa a punto di terapie preventive.
Sponsorizzazione: che cosa era il supporto della Fondazione? Una borsa di studio? Acquisto di materiale per il laboratorio? Donazione di fondi al CNR per il progetto
Pubblicazione: rivista PNAS anno 2019 volume 116 pagine 5108-5117
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FROM `jml_content` AS `a`
LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid`
LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by`
LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by`
LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id`
LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id`
LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id`
WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray14,:preparedArray15)
ORDER BY a.publish_up DESC LIMIT 1511.12ms87.66KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`555μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`573μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`499μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `params`
FROM `jml_comprofiler_plugin`
WHERE `id` = 1168μs11.88KBCopySELECT `id`
FROM `jml_rstbox`
WHERE `published` = 1 AND `testmode` = 0126μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 3172μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 3 AND `visitorid` = '78004de9325f5458' AND MONTH(date) = 03 AND YEAR(date) = 2025272μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 5166μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 5 AND `visitorid` = '78004de9325f5458'152μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT `language`,`id`
FROM `jml_menu`
WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0751μs976B/libraries/src/Language/Multilanguage.php:123CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id276μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id216μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid`
FROM `jml_content` AS `c`
INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context
INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key`
INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id`
INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2
WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-24 21:20:54') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-24 21:20:54') AND c2.state = 1392μs1.81KBParams/libraries/src/Language/Associations.php:145CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
FROM jml_fields AS a
LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language
LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access
LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id
LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
WHERE
(
(`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND
(`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform
ORDER BY a.ordering ASC940μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count
FROM `jml_scheduler_tasks` AS `a`
WHERE `a`.`state` = 1226μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517CopySHOW TABLES1.31ms8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678CopySELECT `session_id`
FROM `jml_session`
WHERE `session_id` = ?157μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291CopyUPDATE `jml_session`
SET `data` = ?
, `time` = ?
WHERE `session_id` = ?8.13ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy