Autori: Garrì F, Russo FP, Carrer T, Weis L, Pistonesi F, Mainardi M, Sandre M, Savarino E, Farinati F, Del Sorbo F, Soliveri P, Calandrella D, Biundo R, Carecchio M, Zecchinelli AL, Pezzoli G, Antonini A.
Significato: la terapia infusionale con levodopa/carbidopa rappresenta una valida ed efficace opzione terapeutica nel Parkinson, nei casi in cui la terapia dopaminergica orale non consente di gestire in modo soddisfacente le fluttuazioni motorie e non motorie che subentrano nella fase avanzata di malattia. Questo studio retrospettivo su 79 pazienti con Parkinson in fase avanzata sottoposti a terapia infusionale con levodopa/carbidopa si poneva come obiettivo primario di analizzare la sicurezza a lungo termine di questo trattamento, raccogliendo tutti gli eventi avversi verificatisi, i dati inerenti la mortalità, la discontinuazione, nonché le cause di interruzione del trattamento e di mortalità e i fattori predittivi (ovvero i fattori correlati), al fine di implementare la ricerca sui criteri di eleggibilità (selezione). Come secondo obiettivo è stata valutata l’efficacia a lungo termine sia sugli aspetti motori della malattia e sia sulla performance cognitiva, Lo studio non soltanto ha confermato i risultati già disponibili in letteratura sull’efficacia della terapia, ma ha evidenziato come l’efficacia del trattamento si mantenga nel lungo termine, non solo per quanto concerne i sintomi motori, ma anche la performance cognitiva.
Sponsorizzazione: borsa di studio per Ricercatore
Pubblicazione: J Neurol. 2022 Oct;269(10):5606-5614. doi: 10.1007/s00415-022-11269-7. Epub 2022 Jul 25. Erratum in: J Neurol. 2022 Aug 20.
Link: Springer
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ORDER BY `m`.`position`,`m`.`ordering`2.68ms132.53KBParams/libraries/src/Cache/Controller/CallbackController.php:51CopySELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count`
FROM `jml_content` AS `a`
LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid`
LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by`
LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by`
LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id`
LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id`
LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id`
WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray14,:preparedArray15)
ORDER BY a.publish_up DESC LIMIT 157.7ms87.66KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`434μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`365μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `params`
FROM `jml_comprofiler_plugin`
WHERE `id` = 1208μs896BCopySELECT `id`
FROM `jml_rstbox`
WHERE `published` = 1 AND `testmode` = 0184μs11.91KB/administrator/components/com_rstbox/EngageBox/Boxes.php:45CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 3135μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 3 AND `visitorid` = '96723bb19827f65a' AND MONTH(date) = 03 AND YEAR(date) = 2025186μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 5138μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 5 AND `visitorid` = '96723bb19827f65a'145μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT `language`,`id`
FROM `jml_menu`
WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0521μs976B/libraries/src/Language/Multilanguage.php:123CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id156μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id144μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid`
FROM `jml_content` AS `c`
INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context
INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key`
INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id`
INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2
WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-23 13:06:52') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-23 13:06:52') AND c2.state = 1339μs1.81KBParams/libraries/src/Language/Associations.php:145CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
FROM jml_fields AS a
LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language
LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access
LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id
LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
WHERE
(
(`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND
(`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform
ORDER BY a.ordering ASC746μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count
FROM `jml_scheduler_tasks` AS `a`
WHERE `a`.`state` = 1179μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517CopySHOW TABLES903μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678CopySELECT `session_id`
FROM `jml_session`
WHERE `session_id` = ?144μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291CopyUPDATE `jml_session`
SET `data` = ?
, `time` = ?
WHERE `session_id` = ?7ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy