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Parte lo studio MOVES-PD

provette ricercaPrimo studio terapeutico in forma ereditaria di Parkinson

 

È stato avviato uno studio clinico in pazienti parkinsoniani in fase iniziale (stadio Hoehn & Yahr 2) portatori di una mutazione del gene GBA che interferisce con lo smaltimento di particolari composti nel cervello. Tutti gli esseri umani hanno due copie di ciascun gene. Chi possiede una copia del GBA mutato può ammalarsi di Parkinson, chi ha entrambe le copie del gene mutate è affetto da una malattia rara, la malattia di Gaucher.

Lo scopo dello studio è di valutare la sicurezza e l’efficacia di diverse dosi di un composto sperimentale detto GZ/SAR40267 che contrasta gli effetti della mutazione, rispetto al placebo (preparato dall'aspetto identico, ma privo del composto attivo). Questa terapia viene somministrata per via orale.

 

Fonte: Comunicato stampa di Sanofi Genzyme

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  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id LEFT JOIN `jml_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC724μs6.37KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`699μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM jml_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1356μs64.88KB/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `jml_modules` AS `m` LEFT JOIN `jml_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`3.63ms132.25KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `metakey` FROM `jml_content` WHERE `id` = :id181μs1.67KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:88Copy
  • SELECT `a`.`id` FROM `jml_content` AS `a` WHERE ( ( (`a`.`id` != :id AND `a`.`state` = 1 AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`metakey` LIKE :preparedArray3 OR `a`.`metakey` LIKE :preparedArray4 OR `a`.`metakey` LIKE :preparedArray5 OR `a`.`metakey` LIKE :preparedArray6 OR `a`.`metakey` LIKE :preparedArray7)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :nowDate1)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray8,:preparedArray9) LIMIT 2029.56ms3.09KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:152Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `jml_content` AS `a` LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`id` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) ORDER BY a.ordering ASC1.49ms87.78KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`543μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`533μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`512μs17.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`511μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`498μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `params` FROM `jml_comprofiler_plugin` WHERE `id` = 1178μs896BCopy
  • SELECT `id` FROM `jml_rstbox` WHERE `published` = 1 AND `testmode` = 0136μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 3139μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 3 AND `visitorid` = 'dd9b2cbf5031f56e' AND MONTH(date) = 03 AND YEAR(date) = 2025184μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 5151μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 5 AND `visitorid` = 'dd9b2cbf5031f56e'163μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT `language`,`id` FROM `jml_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0607μs976B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id132μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id109μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `jml_content` AS `c` INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-24 10:16:27') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-24 10:16:27') AND c2.state = 1389μs1.81KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC786μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `jml_scheduler_tasks` AS `a` WHERE `a`.`state` = 1160μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517Copy
  • SHOW TABLES1.06ms8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678Copy
  • SELECT `session_id` FROM `jml_session` WHERE `session_id` = ?166μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `jml_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?8.02ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy