Risale ad un paio di anni fa l'annuncio che è possibile ringiovanire cellule mature della pelle per ottenere cellule staminali con tutte le proprietà di quelle embrionali, tramite l'inserimento di 4 geni, utilizzando un virus per il trasporto all'interno delle cellule. Il trasporto virale rappresentava un rischio, anche se si usavano virus "attenuati" con capacità riproduttive molto scarse.
Ricercatori americani e tedeschi hanno ora messo a punto un metodo che non richiede più un trasportatore virale. Mediante tecniche di ingegneria genetica hanno costruito una grossa molecola, che racchiude sia i 4 geni da inserire nelle cellule che una proteina che è in grado di attraversare la membrana cellulare e di trascinare i 4 geni all'interno di essa. Pertanto, è sufficiente immergere le cellule della pelle da trasformare in una soluzione contenente le grosse molecole, che migreranno al loro interno.
| Joomla! Version | 4.4.12 |
| PHP Version | 7.4.32 |
| Identity | guest |
| Response | 200 |
| Template | yootheme |
| Database |
|
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| 1 x afterRenderRawModule mod_related_items (Notizie correlate) (534.84KB) (7.46%) | 30.43ms |
| 1 x afterLoad (4.38MB) (5.62%) | 22.90ms |
| 1 x afterRoute (2.38MB) (5.04%) | 20.57ms |
| 1 x afterRenderRawModule mod_menu () (725.7KB) (4.77%) | 19.44ms |
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| 1 x afterRenderComponent com_content (27.55KB) (1.57%) | 6.40ms |
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| 1 x beforeRenderModule mod_menu (Footer Menu) (720B) (0%) | 14μs |
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| 1 x beforeRenderModule mod_custom (Parkinsonews) (720B) (0%) | 11μs |
SELECT @@SESSION.sql_mode;116μs1.61KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334CopySELECT `data`
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FROM `jml_assets`
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FROM `jml_assets`
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SET `hits` = (`hits` + 1)
WHERE `id` = '2252'6.82ms56B/libraries/src/Table/Table.php:1325CopySELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count`
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(
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FROM `jml_categories` AS `s`
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ORDER BY `c`.`lft`497μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `m`.`tag_id`,`t`.*
FROM `jml_contentitem_tag_map` AS `m`
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WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)299μs5.5KBParams/libraries/src/Helper/TagsHelper.php:388CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`655μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
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LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
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LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
LEFT JOIN `jml_fields_categories` AS fc ON fc.field_id = a.id
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(
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FROM `jml_categories` AS `s`
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(
(
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FROM `jml_content`
WHERE `id` = :id240μs1.67KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:88CopySELECT `a`.`id`
FROM `jml_content` AS `a`
WHERE
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(
(`a`.`id` != :id AND `a`.`state` = 1 AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
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(`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :nowDate1)) AND
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FROM `jml_content` AS `a`
LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid`
LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by`
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LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id`
WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`id` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown)
ORDER BY a.ordering ASC807μs50.08KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`485μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`436μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`427μs17.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `params`
FROM `jml_comprofiler_plugin`
WHERE `id` = 1167μs896BCopySELECT `id`
FROM `jml_rstbox`
WHERE `published` = 1 AND `testmode` = 0196μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 3172μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 3 AND `visitorid` = 'c50b0dfa7582ad8a' AND MONTH(date) = 03 AND YEAR(date) = 2025181μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 5171μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 5 AND `visitorid` = 'c50b0dfa7582ad8a'145μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT `language`,`id`
FROM `jml_menu`
WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0453μs976B/libraries/src/Language/Multilanguage.php:123CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id138μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id118μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid`
FROM `jml_content` AS `c`
INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context
INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key`
INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id`
INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2
WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-25 01:51:04') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-25 01:51:04') AND c2.state = 1317μs1.81KBParams/libraries/src/Language/Associations.php:145CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
FROM jml_fields AS a
LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language
LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access
LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id
LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
WHERE
(
(`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND
(`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform
ORDER BY a.ordering ASC724μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count
FROM `jml_scheduler_tasks` AS `a`
WHERE `a`.`state` = 1246μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517CopySHOW TABLES723μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678CopySELECT `session_id`
FROM `jml_session`
WHERE `session_id` = ?166μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291CopyUPDATE `jml_session`
SET `data` = ?
, `time` = ?
WHERE `session_id` = ?18.4ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy