Skip to main content

Alfa-sinucleina nel sangue per diagnosticare il Parkinson?

Livelli nei globuli rossi permetterebbero di distinguere parkinsoniani da controlli sani

Nell’ambito dello studio BioFIND, uno studio osservazionale con lo scopo di trovare parametri biologici utili per la diagnosi di malattia di Parkinson, sono stati misurati i livelli di diverse forme della proteina alfa-sinucleina nei globuli rossi di 46 pazienti parkinsoniani, tra cui 32 con sintomi motori e 14 con sintomi di demenza alla valutazione cognitiva di Montreal, e 45 controlli sani. Le forme di alfa-sinucleina misurate tramite un test ELISA sono state: alfa-sinucleina totale, alfa-sinucleina malripiegata, fosforilata ed ossidata (tutte forme che promuovono gli accumuli anormali nelle cellule nervose malate di Parkinson detti corpi di Lewy).

È stato rilevato che i livelli di alfa-sinucleina malripiegata e di alfa-sinucleina fosforilata, ma non l’alfa-sinucleina totale o quella ossidata, permettevano di distinguere i pazienti con sintomatologia motoria dai controlli, mentre questo non era possibile per i pazienti con problemi cognitivi.

Lo studio è stato ripetuto confrontando 35 pazienti parkinsoniani con sintomatologia motoria e 28 controlli sani ed i risultati sono stati gli stessi.

I ricercatori (un gruppo israeliano + un gruppo italiano) sono giunti alla conclusione che la misurazione dei livelli di alfa-sinucleina malripiegata e fosforilata potrebbe essere un biomarcatore utile per la diagnosi di malattia di Parkinson. Per confermare il suo uso serve un altro studio longitudinale per valutare l’andamento delle due forme di alfa-sinucleina nel corso della malattia.

Ricordiamo che la Fondazione Grigioni sta mettendo a punto un esame diagnostico basato sul livello di alfa-sinucleina in biopsie di pelle (vedere notizia sul sito).

 

Fonte: Elhadi A e coll Ann Clin transl neurol online 6 dicembre 2019

 

parkinsonews
J! InfoRequestSessionProfileQueries50
37.306MBMemory Usage350msRequest Duration
Joomla! Version4.4.12
PHP Version7.4.32
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
5.7.40-log
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_general_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
array:1 [ "nrid" => "d590c650ecceacad" ]
$_SERVER
array:49 [ "REDIRECT_SCRIPT_URL" => "/it/varie/alfa-sinucleina-nel-sangue-per-diagnosticare-il-par...
session
array:3 [ "counter" => 1 "timer" => array:3 [ "start" => 1742884610 "last" => 1742884610...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:18 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
plg_system_languagefilter
array:1 [ "language" => "it-IT" ]
  • afterLoad (4.38MB) (23.13ms)
  • afterInitialise (9.16MB) (72.67ms)
  • afterRoute (2.38MB) (21.75ms)
  • beforeRenderComponent com_content (427.37KB) (2.88ms)
  • Before Access::preloadComponents (all components) (503.46KB) (3.48ms)
  • After Access::preloadComponents (all components) (130.11KB) (1.11ms)
  • Before Access::preloadPermissions (com_content) (4.74KB) (27μs)
  • After Access::preloadPermissions (com_content) (1.88MB) (7.25ms)
  • Before Access::getAssetRules (id:4008 name:com_content.article.3374) (131.17KB) (109μs)
  • After Access::getAssetRules (id:4008 name:com_content.article.3374) (94.67KB) (304μs)
  • beforeRenderRawModule mod_related_items (Notizie correlate) (10.96MB) (111ms)
  • afterRenderRawModule mod_related_items (Notizie correlate) (638.77KB) (13.29ms)
  • beforeRenderModule mod_related_items (Notizie correlate) (720B) (12μs)
  • afterRenderModule mod_related_items (Notizie correlate) (7.58KB) (214μs)
  • beforeRenderRawModule mod_syndicate (Feed RSS) (9.87KB) (693μs)
  • afterRenderRawModule mod_syndicate (Feed RSS) (12.88KB) (792μs)
  • beforeRenderModule mod_syndicate (Feed RSS) (720B) (10μs)
  • afterRenderModule mod_syndicate (Feed RSS) (2.52KB) (85μs)
  • beforeRenderRawModule mod_custom (Parkinsonews) (9.57KB) (413μs)
  • afterRenderRawModule mod_custom (Parkinsonews) (9.7KB) (630μs)
  • beforeRenderModule mod_custom (Parkinsonews) (720B) (8μs)
  • afterRenderModule mod_custom (Parkinsonews) (1.25KB) (69μs)
  • beforeRenderRawModule mod_menu (Footer Menu) (19.36KB) (670μs)
  • afterRenderRawModule mod_menu (Footer Menu) (3.7MB) (23.74ms)
  • beforeRenderModule mod_menu (Footer Menu) (720B) (10μs)
  • afterRenderModule mod_menu (Footer Menu) (4.23KB) (125μs)
  • afterRenderComponent com_content (38.55KB) (4.23ms)
  • Before Access::getAssetRules (id:1 name:root.1) (474.64KB) (4.7ms)
  • After Access::getAssetRules (id:1 name:root.1) (7.73KB) (48μs)
  • Before Access::getAssetRules (id:8 name:com_content) (650.29KB) (10.11ms)
  • After Access::getAssetRules (id:8 name:com_content) (7.73KB) (50μs)
  • afterDispatch (23.39KB) (960μs)
  • beforeRenderRawModule mod_menu () (70.55KB) (5.04ms)
  • afterRenderRawModule mod_menu () (724.45KB) (10.97ms)
  • beforeRenderModule mod_menu () (696B) (9μs)
  • afterRenderModule mod_menu () (1.23KB) (100μs)
  • beforeRenderRawModule mod_menu () (15.77KB) (718μs)
  • afterRenderRawModule mod_menu () (17.77KB) (6.91ms)
  • beforeRenderModule mod_menu () (696B) (8μs)
  • afterRenderModule mod_menu () (10.27KB) (99μs)
  • beforeRenderRawModule mod_custom () (9.23KB) (24μs)
  • afterRenderRawModule mod_custom () (15.96KB) (1.73ms)
  • beforeRenderModule mod_custom () (704B) (9μs)
  • afterRenderModule mod_custom () (2.43KB) (74μs)
  • beforeRenderRawModule mod_custom () (10.81KB) (634μs)
  • afterRenderRawModule mod_custom () (960B) (220μs)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (2.71KB) (65μs)
  • beforeRenderRawModule mod_menu () (3.47KB) (414μs)
  • afterRenderRawModule mod_menu () (98.8KB) (1.96ms)
  • beforeRenderModule mod_menu () (696B) (8μs)
  • afterRenderModule mod_menu () (1.23KB) (77μs)
  • beforeRenderRawModule mod_menu () (4.64KB) (449μs)
  • afterRenderRawModule mod_menu () (29.01KB) (5.95ms)
  • beforeRenderModule mod_menu () (696B) (9μs)
  • afterRenderModule mod_menu () (1.23KB) (75μs)
  • beforeRenderRawModule mod_custom () (12.17KB) (477μs)
  • afterRenderRawModule mod_custom () (912B) (217μs)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (2.43KB) (65μs)
  • beforeRenderRawModule mod_custom () (2.97KB) (428μs)
  • afterRenderRawModule mod_custom () (912B) (200μs)
  • beforeRenderModule mod_custom () (704B) (6μs)
  • afterRenderModule mod_custom () (2.71KB) (64μs)
  • afterRender (541.03KB) (7.36ms)
  • 1 x beforeRenderRawModule mod_related_items (Notizie correlate) (10.96MB) (31.64%)
    110.71ms
    1 x afterInitialise (9.16MB) (20.77%)
    72.67ms
    1 x afterRenderRawModule mod_menu (Footer Menu) (3.7MB) (6.78%)
    23.74ms
    1 x afterLoad (4.38MB) (6.61%)
    23.13ms
    1 x afterRoute (2.38MB) (6.22%)
    21.75ms
    1 x afterRenderRawModule mod_related_items (Notizie correlate) (638.77KB) (3.8%)
    13.29ms
    1 x afterRenderRawModule mod_menu () (724.45KB) (3.14%)
    10.97ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (650.29KB) (2.89%)
    10.11ms
    1 x afterRender (541.03KB) (2.1%)
    7.36ms
    1 x After Access::preloadPermissions (com_content) (1.88MB) (2.07%)
    7.25ms
    1 x afterRenderRawModule mod_menu () (17.77KB) (1.97%)
    6.91ms
    1 x afterRenderRawModule mod_menu () (29.01KB) (1.7%)
    5.95ms
    1 x beforeRenderRawModule mod_menu () (70.55KB) (1.44%)
    5.04ms
    1 x Before Access::getAssetRules (id:1 name:root.1) (474.64KB) (1.34%)
    4.70ms
    1 x afterRenderComponent com_content (38.55KB) (1.21%)
    4.23ms
    1 x Before Access::preloadComponents (all components) (503.46KB) (0.99%)
    3.48ms
    1 x beforeRenderComponent com_content (427.37KB) (0.82%)
    2.88ms
    1 x afterRenderRawModule mod_menu () (98.8KB) (0.56%)
    1.96ms
    1 x afterRenderRawModule mod_custom () (15.96KB) (0.49%)
    1.73ms
    1 x After Access::preloadComponents (all components) (130.11KB) (0.32%)
    1.11ms
    1 x afterDispatch (23.39KB) (0.27%)
    960μs
    1 x afterRenderRawModule mod_syndicate (Feed RSS) (12.88KB) (0.23%)
    792μs
    1 x beforeRenderRawModule mod_menu () (15.77KB) (0.21%)
    718μs
    1 x beforeRenderRawModule mod_syndicate (Feed RSS) (9.87KB) (0.2%)
    693μs
    1 x beforeRenderRawModule mod_menu (Footer Menu) (19.36KB) (0.19%)
    670μs
    1 x beforeRenderRawModule mod_custom () (10.81KB) (0.18%)
    634μs
    1 x afterRenderRawModule mod_custom (Parkinsonews) (9.7KB) (0.18%)
    630μs
    1 x beforeRenderRawModule mod_custom () (12.17KB) (0.14%)
    477μs
    1 x beforeRenderRawModule mod_menu () (4.64KB) (0.13%)
    449μs
    1 x beforeRenderRawModule mod_custom () (2.97KB) (0.12%)
    428μs
    2 x afterRenderRawModule mod_custom () (912B) (0.12%)
    417μs
    1 x beforeRenderRawModule mod_menu () (3.47KB) (0.12%)
    414μs
    1 x beforeRenderRawModule mod_custom (Parkinsonews) (9.57KB) (0.12%)
    413μs
    1 x After Access::getAssetRules (id:4008 name:com_content.article.3374) (94.67KB) (0.09%)
    304μs
    3 x afterRenderModule mod_menu () (1.23KB) (0.07%)
    252μs
    1 x afterRenderRawModule mod_custom () (960B) (0.06%)
    220μs
    1 x afterRenderModule mod_related_items (Notizie correlate) (7.58KB) (0.06%)
    214μs
    2 x afterRenderModule mod_custom () (2.43KB) (0.04%)
    139μs
    2 x afterRenderModule mod_custom () (2.71KB) (0.04%)
    129μs
    1 x afterRenderModule mod_menu (Footer Menu) (4.23KB) (0.04%)
    125μs
    1 x Before Access::getAssetRules (id:4008 name:com_content.article.3374) (131.17KB) (0.03%)
    109μs
    1 x afterRenderModule mod_menu () (10.27KB) (0.03%)
    99μs
    1 x afterRenderModule mod_syndicate (Feed RSS) (2.52KB) (0.02%)
    85μs
    1 x afterRenderModule mod_custom (Parkinsonews) (1.25KB) (0.02%)
    69μs
    1 x After Access::getAssetRules (id:8 name:com_content) (7.73KB) (0.01%)
    50μs
    1 x After Access::getAssetRules (id:1 name:root.1) (7.73KB) (0.01%)
    48μs
    4 x beforeRenderModule mod_menu () (696B) (0.01%)
    34μs
    4 x beforeRenderModule mod_custom () (704B) (0.01%)
    29μs
    1 x Before Access::preloadPermissions (com_content) (4.74KB) (0.01%)
    27μs
    1 x beforeRenderRawModule mod_custom () (9.23KB) (0.01%)
    24μs
    1 x beforeRenderModule mod_related_items (Notizie correlate) (720B) (0%)
    12μs
    1 x beforeRenderModule mod_syndicate (Feed RSS) (720B) (0%)
    10μs
    1 x beforeRenderModule mod_menu (Footer Menu) (720B) (0%)
    10μs
    1 x beforeRenderModule mod_custom (Parkinsonews) (720B) (0%)
    8μs
50 statements were executed, 7 of which were duplicates, 43 unique57.66ms1.4MB
UniquesDuplicates 1Duplicates 2Duplicates 3
  • SELECT @@SESSION.sql_mode;105μs1.61KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `jml_session` WHERE `session_id` = ?163μs1.63KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `jml_session` WHERE `session_id` = :session_id LIMIT 1121μs1.63KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `jml_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)8.3ms976BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `jml_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1396μs21.39KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `jml_viewlevels`132μs1.22KB/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `jml_usergroups` AS `a` LEFT JOIN `jml_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest168μs1.7KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `jml_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`911μs16.84KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `jml_languages` WHERE `published` = 1 ORDER BY `ordering` ASC271μs4.05KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `jml_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1171μs1.48KB/libraries/src/Language/LanguageHelper.php:213Copy
  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `jml_menu` AS `m` LEFT JOIN `jml_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`2.02ms203.69KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`473μs6.84KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id` FROM `jml_content` WHERE `alias` = :alias AND `catid` = :catid185μs1.7KBParams/components/com_content/src/Service/Router.php:263Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `jml_template_styles` AS `s` LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1281μs17.4KB/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SHOW TABLES728μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `jml_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44)663μs11.41KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `jml_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 03.28ms444.34KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `jml_content`360μs10.48KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `jml_content` SET `hits` = (`hits` + 1) WHERE `id` = '3374'16.66ms56B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `jml_content` AS `a` INNER JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `jml_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)433μs25.72KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`440μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `jml_contentitem_tag_map` AS `m` INNER JOIN `jml_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)254μs5.5KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`408μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id LEFT JOIN `jml_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC543μs6.37KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`548μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM jml_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1330μs64.88KB/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `jml_modules` AS `m` LEFT JOIN `jml_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`2.59ms132.25KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `metakey` FROM `jml_content` WHERE `id` = :id147μs1.67KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:88Copy
  • SELECT `a`.`id` FROM `jml_content` AS `a` WHERE ( ( (`a`.`id` != :id AND `a`.`state` = 1 AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`metakey` LIKE :preparedArray3 OR `a`.`metakey` LIKE :preparedArray4 OR `a`.`metakey` LIKE :preparedArray5 OR `a`.`metakey` LIKE :preparedArray6 OR `a`.`metakey` LIKE :preparedArray7 OR `a`.`metakey` LIKE :preparedArray8 OR `a`.`metakey` LIKE :preparedArray9 OR `a`.`metakey` LIKE :preparedArray10 OR `a`.`metakey` LIKE :preparedArray11 OR `a`.`metakey` LIKE :preparedArray12 OR `a`.`metakey` LIKE :preparedArray13 OR `a`.`metakey` LIKE :preparedArray14 OR `a`.`metakey` LIKE :preparedArray15)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :nowDate1)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray16,:preparedArray17) LIMIT 20546μs4.84KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:152Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `jml_content` AS `a` LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`id` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) ORDER BY a.ordering ASC1.89ms332.03KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`406μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`347μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`333μs17.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`327μs6.38KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`327μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `params` FROM `jml_comprofiler_plugin` WHERE `id` = 1175μs896BCopy
  • SELECT `id` FROM `jml_rstbox` WHERE `published` = 1 AND `testmode` = 0172μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 3161μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 3 AND `visitorid` = 'd590c650ecceacad' AND MONTH(date) = 03 AND YEAR(date) = 2025174μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 5128μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 5 AND `visitorid` = 'd590c650ecceacad'119μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT `language`,`id` FROM `jml_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0458μs976B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id122μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id87μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `jml_content` AS `c` INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-25 06:36:50') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-25 06:36:50') AND c2.state = 1284μs1.81KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC668μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `jml_scheduler_tasks` AS `a` WHERE `a`.`state` = 1182μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517Copy
  • SHOW TABLES773μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678Copy
  • SELECT `session_id` FROM `jml_session` WHERE `session_id` = ?146μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `jml_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?8.75ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy