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Vettori virali nella terapia genica della malattia di Parkinson

I vettori basati sul virus Herpes simplex presentano particolari vantaggi

Le procedure di terapia genica per la malattia di Parkinson potrebbero richiedere il trasporto di un gene che codifica la produzione di dopamina oppure il trasporto di geni che codificano la produzione di fattori neurotrofici che sostengono la sopravvivenza dei neuroni dopaminergici.
Tra le varie alternative, i vettori basati sul virus herpes simplex sono potenzialmente in grado di trasportare geni terapeutici multipli.

parkinsonews
J! InfoRequestSessionProfileQueries51
37.296MBMemory Usage335msRequest Duration
Joomla! Version4.4.12
PHP Version7.4.32
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
5.7.40-log
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_general_ci
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plg_system_languagefilter
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  • afterLoad (4.38MB) (22.49ms)
  • afterInitialise (9.16MB) (67.95ms)
  • afterRoute (2.38MB) (19.49ms)
  • beforeRenderComponent com_content (427.37KB) (2.53ms)
  • Before Access::preloadComponents (all components) (503.46KB) (3.15ms)
  • After Access::preloadComponents (all components) (130.11KB) (1.32ms)
  • Before Access::preloadPermissions (com_content) (4.74KB) (24μs)
  • After Access::preloadPermissions (com_content) (1.88MB) (6.37ms)
  • Before Access::getAssetRules (id:8948 name:com_content.article.1211) (131.17KB) (116μs)
  • After Access::getAssetRules (id:8948 name:com_content.article.1211) (94.67KB) (366μs)
  • beforeRenderRawModule mod_related_items (Notizie correlate) (10.95MB) (101ms)
  • afterRenderRawModule mod_related_items (Notizie correlate) (665.38KB) (14.71ms)
  • beforeRenderModule mod_related_items (Notizie correlate) (720B) (14μs)
  • afterRenderModule mod_related_items (Notizie correlate) (7.58KB) (258μs)
  • beforeRenderRawModule mod_syndicate (Feed RSS) (9.87KB) (791μs)
  • afterRenderRawModule mod_syndicate (Feed RSS) (12.88KB) (710μs)
  • beforeRenderModule mod_syndicate (Feed RSS) (720B) (9μs)
  • afterRenderModule mod_syndicate (Feed RSS) (2.52KB) (84μs)
  • beforeRenderRawModule mod_custom (Parkinsonews) (9.57KB) (424μs)
  • afterRenderRawModule mod_custom (Parkinsonews) (9.7KB) (571μs)
  • beforeRenderModule mod_custom (Parkinsonews) (720B) (7μs)
  • afterRenderModule mod_custom (Parkinsonews) (1.25KB) (67μs)
  • beforeRenderRawModule mod_menu (Footer Menu) (19.36KB) (704μs)
  • afterRenderRawModule mod_menu (Footer Menu) (3.7MB) (24.43ms)
  • beforeRenderModule mod_menu (Footer Menu) (720B) (13μs)
  • afterRenderModule mod_menu (Footer Menu) (4.23KB) (145μs)
  • afterRenderComponent com_content (25.92KB) (4.15ms)
  • Before Access::getAssetRules (id:1 name:root.1) (474.64KB) (4.88ms)
  • After Access::getAssetRules (id:1 name:root.1) (7.73KB) (41μs)
  • Before Access::getAssetRules (id:8 name:com_content) (650.35KB) (10.79ms)
  • After Access::getAssetRules (id:8 name:com_content) (7.73KB) (49μs)
  • afterDispatch (23.39KB) (1.07ms)
  • beforeRenderRawModule mod_menu () (70.55KB) (5.15ms)
  • afterRenderRawModule mod_menu () (724.45KB) (11.14ms)
  • beforeRenderModule mod_menu () (696B) (10μs)
  • afterRenderModule mod_menu () (1.23KB) (109μs)
  • beforeRenderRawModule mod_menu () (15.77KB) (744μs)
  • afterRenderRawModule mod_menu () (17.77KB) (6.94ms)
  • beforeRenderModule mod_menu () (696B) (10μs)
  • afterRenderModule mod_menu () (10.27KB) (108μs)
  • beforeRenderRawModule mod_custom () (9.23KB) (27μs)
  • afterRenderRawModule mod_custom () (15.96KB) (1.97ms)
  • beforeRenderModule mod_custom () (704B) (8μs)
  • afterRenderModule mod_custom () (2.43KB) (88μs)
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  • afterRenderRawModule mod_custom () (960B) (236μs)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (2.71KB) (65μs)
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  • afterRenderRawModule mod_menu () (98.8KB) (2.09ms)
  • beforeRenderModule mod_menu () (696B) (8μs)
  • afterRenderModule mod_menu () (1.23KB) (82μs)
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  • afterRenderRawModule mod_menu () (29.01KB) (6.02ms)
  • beforeRenderModule mod_menu () (696B) (9μs)
  • afterRenderModule mod_menu () (1.23KB) (83μs)
  • beforeRenderRawModule mod_custom () (12.17KB) (490μs)
  • afterRenderRawModule mod_custom () (912B) (257μs)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (2.43KB) (66μs)
  • beforeRenderRawModule mod_custom () (2.97KB) (433μs)
  • afterRenderRawModule mod_custom () (912B) (211μs)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (2.71KB) (64μs)
  • afterRender (533.03KB) (7.54ms)
  • 1 x beforeRenderRawModule mod_related_items (Notizie correlate) (10.95MB) (30.05%)
    100.75ms
    1 x afterInitialise (9.16MB) (20.27%)
    67.95ms
    1 x afterRenderRawModule mod_menu (Footer Menu) (3.7MB) (7.29%)
    24.43ms
    1 x afterLoad (4.38MB) (6.71%)
    22.49ms
    1 x afterRoute (2.38MB) (5.81%)
    19.49ms
    1 x afterRenderRawModule mod_related_items (Notizie correlate) (665.38KB) (4.39%)
    14.71ms
    1 x afterRenderRawModule mod_menu () (724.45KB) (3.32%)
    11.14ms
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    1 x afterRenderRawModule mod_menu () (17.77KB) (2.07%)
    6.94ms
    1 x After Access::preloadPermissions (com_content) (1.88MB) (1.9%)
    6.37ms
    1 x afterRenderRawModule mod_menu () (29.01KB) (1.8%)
    6.02ms
    1 x beforeRenderRawModule mod_menu () (70.55KB) (1.54%)
    5.15ms
    1 x Before Access::getAssetRules (id:1 name:root.1) (474.64KB) (1.45%)
    4.88ms
    1 x afterRenderComponent com_content (25.92KB) (1.24%)
    4.15ms
    1 x Before Access::preloadComponents (all components) (503.46KB) (0.94%)
    3.15ms
    1 x beforeRenderComponent com_content (427.37KB) (0.75%)
    2.53ms
    1 x afterRenderRawModule mod_menu () (98.8KB) (0.62%)
    2.09ms
    1 x afterRenderRawModule mod_custom () (15.96KB) (0.59%)
    1.97ms
    1 x After Access::preloadComponents (all components) (130.11KB) (0.39%)
    1.32ms
    1 x afterDispatch (23.39KB) (0.32%)
    1.07ms
    1 x beforeRenderRawModule mod_syndicate (Feed RSS) (9.87KB) (0.24%)
    791μs
    1 x beforeRenderRawModule mod_menu () (15.77KB) (0.22%)
    744μs
    1 x afterRenderRawModule mod_syndicate (Feed RSS) (12.88KB) (0.21%)
    710μs
    1 x beforeRenderRawModule mod_menu (Footer Menu) (19.36KB) (0.21%)
    704μs
    1 x beforeRenderRawModule mod_custom () (10.81KB) (0.19%)
    648μs
    1 x afterRenderRawModule mod_custom (Parkinsonews) (9.7KB) (0.17%)
    571μs
    1 x beforeRenderRawModule mod_custom () (12.17KB) (0.15%)
    490μs
    2 x afterRenderRawModule mod_custom () (912B) (0.14%)
    468μs
    1 x beforeRenderRawModule mod_menu () (4.64KB) (0.14%)
    463μs
    1 x beforeRenderRawModule mod_custom () (2.97KB) (0.13%)
    433μs
    1 x beforeRenderRawModule mod_custom (Parkinsonews) (9.57KB) (0.13%)
    424μs
    1 x beforeRenderRawModule mod_menu () (3.47KB) (0.12%)
    417μs
    1 x After Access::getAssetRules (id:8948 name:com_content.article.1211) (94.67KB) (0.11%)
    366μs
    3 x afterRenderModule mod_menu () (1.23KB) (0.08%)
    274μs
    1 x afterRenderModule mod_related_items (Notizie correlate) (7.58KB) (0.08%)
    258μs
    1 x afterRenderRawModule mod_custom () (960B) (0.07%)
    236μs
    2 x afterRenderModule mod_custom () (2.43KB) (0.05%)
    154μs
    1 x afterRenderModule mod_menu (Footer Menu) (4.23KB) (0.04%)
    145μs
    2 x afterRenderModule mod_custom () (2.71KB) (0.04%)
    129μs
    1 x Before Access::getAssetRules (id:8948 name:com_content.article.1211) (131.17KB) (0.03%)
    116μs
    1 x afterRenderModule mod_menu () (10.27KB) (0.03%)
    108μs
    1 x afterRenderModule mod_syndicate (Feed RSS) (2.52KB) (0.03%)
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    1 x afterRenderModule mod_custom (Parkinsonews) (1.25KB) (0.02%)
    67μs
    1 x After Access::getAssetRules (id:8 name:com_content) (7.73KB) (0.01%)
    49μs
    1 x After Access::getAssetRules (id:1 name:root.1) (7.73KB) (0.01%)
    41μs
    4 x beforeRenderModule mod_menu () (696B) (0.01%)
    37μs
    4 x beforeRenderModule mod_custom () (704B) (0.01%)
    29μs
    1 x beforeRenderRawModule mod_custom () (9.23KB) (0.01%)
    27μs
    1 x Before Access::preloadPermissions (com_content) (4.74KB) (0.01%)
    24μs
    1 x beforeRenderModule mod_related_items (Notizie correlate) (720B) (0%)
    14μs
    1 x beforeRenderModule mod_menu (Footer Menu) (720B) (0%)
    13μs
    1 x beforeRenderModule mod_syndicate (Feed RSS) (720B) (0%)
    9μs
    1 x beforeRenderModule mod_custom (Parkinsonews) (720B) (0%)
    7μs
51 statements were executed, 7 of which were duplicates, 44 unique48.31ms1.39MB
UniquesDuplicates 1Duplicates 2Duplicates 3
  • SELECT @@SESSION.sql_mode;109μs1.61KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `jml_session` WHERE `session_id` = ?169μs1.63KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `jml_session` WHERE `session_id` = :session_id LIMIT 1132μs1.63KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `jml_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)7.71ms976BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `jml_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1439μs21.39KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `jml_viewlevels`138μs1.22KB/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `jml_usergroups` AS `a` LEFT JOIN `jml_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest164μs1.7KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `jml_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`906μs16.84KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `jml_languages` WHERE `published` = 1 ORDER BY `ordering` ASC274μs4.05KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `jml_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1174μs1.48KB/libraries/src/Language/LanguageHelper.php:213Copy
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  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`466μs6.84KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id` FROM `jml_content` WHERE `alias` = :alias AND `catid` = :catid188μs1.7KBParams/components/com_content/src/Service/Router.php:263Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `jml_template_styles` AS `s` LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1300μs17.4KB/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SHOW TABLES730μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `jml_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44)729μs11.41KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `jml_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 03.22ms444.34KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `jml_content`380μs10.48KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `jml_content` SET `hits` = (`hits` + 1) WHERE `id` = '1211'7.8ms56B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `jml_content` AS `a` INNER JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `jml_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)437μs9.72KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`430μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
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  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`465μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id LEFT JOIN `jml_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC575μs6.37KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`600μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM jml_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1348μs64.88KB/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `jml_modules` AS `m` LEFT JOIN `jml_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`2.72ms132.25KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `metakey` FROM `jml_content` WHERE `id` = :id181μs1.67KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:88Copy
  • SELECT `a`.`id` FROM `jml_content` AS `a` WHERE ( ( (`a`.`id` != :id AND `a`.`state` = 1 AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`metakey` LIKE :preparedArray3 OR `a`.`metakey` LIKE :preparedArray4 OR `a`.`metakey` LIKE :preparedArray5 OR `a`.`metakey` LIKE :preparedArray6 OR `a`.`metakey` LIKE :preparedArray7 OR `a`.`metakey` LIKE :preparedArray8)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :nowDate1)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray9,:preparedArray10) LIMIT 20707μs3.41KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:152Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `jml_content` AS `a` LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`id` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) ORDER BY a.ordering ASC1.99ms332.03KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`424μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`357μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`338μs17.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`324μs6.38KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`327μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `jml_categories` AS `s` INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`323μs6.9KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `params` FROM `jml_comprofiler_plugin` WHERE `id` = 1191μs896BCopy
  • SELECT `id` FROM `jml_rstbox` WHERE `published` = 1 AND `testmode` = 0205μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 3150μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 3 AND `visitorid` = 'ffaf9c1a1082dd70' AND MONTH(date) = 03 AND YEAR(date) = 2025202μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT * FROM `jml_rstbox` WHERE `id` = 5142μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238Copy
  • SELECT COUNT(id) FROM `jml_rstbox_logs` WHERE `event` = 1 AND `box` = 5 AND `visitorid` = 'ffaf9c1a1082dd70'125μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201Copy
  • SELECT `language`,`id` FROM `jml_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0462μs976B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id168μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `jml_content` WHERE `id` = :id106μs1.67KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `jml_content` AS `c` INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-24 20:29:04') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-24 20:29:04') AND c2.state = 1321μs1.81KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM jml_fields AS a LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language LEFT JOIN jml_users AS uc ON uc.id=a.checked_out LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform ORDER BY a.ordering ASC747μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `jml_scheduler_tasks` AS `a` WHERE `a`.`state` = 1216μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517Copy
  • SHOW TABLES748μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678Copy
  • SELECT `session_id` FROM `jml_session` WHERE `session_id` = ?166μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `jml_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?7.54ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy