Portatori di mutazioni LRRK2 hanno malattia meno grave
Sono state confrontate le caratteristiche principali per quanto riguarda la sintomatologia motoria e non motoria, nonché le immagini DATscan tra 158 pazienti parkinsoniani portatori di mutazione del gene LRRK2 (89% variante G2019S), 80 pazienti parkinsoniani portatori di mutazione del gene GBA (80% variante N370S) e 361 pazienti con malattia di Parkinson sporadica ovvero senza mutazioni genetiche note. La durata di malattia dei tre gruppi era mediamente di 2,9 anni, 3,1 anni e 2,6 anni. I pazienti con mutazioni del gene LRRK2, presentavano sintomi motori di gravità inferiore, nonché una perdita inferiore delle cellule nervose nelle immagini DATscan rispetto ai pazienti con malattia sporadica, mentre i pazienti con mutazioni GBA presentavano sintomatologia di gravità sovrapponibile anche se la perdita delle cellule nervose era inferiore nelle immagini DATscan.
Rimane da stabilire l’entità della progressione della malattia nel tempo nei portatori di mutazioni dei due geni.
| Joomla! Version | 4.4.12 |
| PHP Version | 7.4.32 |
| Identity | guest |
| Response | 200 |
| Template | yootheme |
| Database |
|
| 1 x beforeRenderRawModule mod_related_items (Notizie correlate) (10.95MB) (32.3%) | 147.29ms |
| 1 x afterInitialise (9.16MB) (20.87%) | 95.15ms |
| 1 x afterRenderRawModule mod_menu (Footer Menu) (3.7MB) (8.11%) | 36.96ms |
| 1 x afterLoad (4.38MB) (7.65%) | 34.88ms |
| 1 x afterRoute (2.38MB) (5.43%) | 24.74ms |
| 1 x afterRenderRawModule mod_related_items (Notizie correlate) (632.66KB) (4.17%) | 19.00ms |
| 1 x afterRenderRawModule mod_menu () (724.45KB) (2.55%) | 11.63ms |
| 1 x Before Access::getAssetRules (id:8 name:com_content) (650.21KB) (2.32%) | 10.57ms |
| 1 x After Access::preloadPermissions (com_content) (1.88MB) (2.22%) | 10.10ms |
| 1 x afterRender (541.03KB) (2.08%) | 9.46ms |
| 1 x afterRenderRawModule mod_menu () (29.01KB) (1.8%) | 8.22ms |
| 1 x afterRenderRawModule mod_menu () (17.77KB) (1.64%) | 7.49ms |
| 1 x beforeRenderRawModule mod_menu () (70.55KB) (1.2%) | 5.48ms |
| 1 x Before Access::getAssetRules (id:1 name:root.1) (474.64KB) (1.05%) | 4.78ms |
| 1 x afterRenderComponent com_content (26.55KB) (1.03%) | 4.69ms |
| 1 x Before Access::preloadComponents (all components) (503.46KB) (0.76%) | 3.46ms |
| 1 x beforeRenderComponent com_content (427.37KB) (0.71%) | 3.23ms |
| 1 x afterRenderRawModule mod_menu () (98.8KB) (0.46%) | 2.10ms |
| 1 x afterRenderRawModule mod_custom () (15.96KB) (0.34%) | 1.55ms |
| 1 x After Access::preloadComponents (all components) (130.11KB) (0.26%) | 1.20ms |
| 1 x afterDispatch (23.45KB) (0.25%) | 1.16ms |
| 1 x afterRenderRawModule mod_syndicate (Feed RSS) (12.88KB) (0.24%) | 1.09ms |
| 1 x beforeRenderRawModule mod_syndicate (Feed RSS) (9.87KB) (0.23%) | 1.06ms |
| 1 x beforeRenderRawModule mod_menu (Footer Menu) (19.36KB) (0.23%) | 1.04ms |
| 1 x afterRenderRawModule mod_custom (Parkinsonews) (9.7KB) (0.2%) | 895μs |
| 1 x beforeRenderRawModule mod_custom () (10.81KB) (0.18%) | 830μs |
| 1 x beforeRenderRawModule mod_menu () (15.77KB) (0.16%) | 730μs |
| 1 x beforeRenderRawModule mod_custom () (12.17KB) (0.15%) | 684μs |
| 2 x afterRenderRawModule mod_custom () (912B) (0.13%) | 610μs |
| 1 x beforeRenderRawModule mod_custom (Parkinsonews) (9.57KB) (0.13%) | 597μs |
| 1 x beforeRenderRawModule mod_custom () (2.97KB) (0.13%) | 571μs |
| 1 x beforeRenderRawModule mod_menu () (3.47KB) (0.12%) | 535μs |
| 1 x beforeRenderRawModule mod_menu () (4.64KB) (0.1%) | 452μs |
| 1 x After Access::getAssetRules (id:4042 name:com_content.article.3392) (94.67KB) (0.07%) | 321μs |
| 1 x afterRenderModule mod_related_items (Notizie correlate) (7.58KB) (0.07%) | 303μs |
| 1 x afterRenderRawModule mod_custom () (960B) (0.06%) | 293μs |
| 3 x afterRenderModule mod_menu () (1.23KB) (0.06%) | 289μs |
| 1 x afterRenderModule mod_menu (Footer Menu) (4.23KB) (0.04%) | 197μs |
| 2 x afterRenderModule mod_custom () (2.71KB) (0.04%) | 184μs |
| 2 x afterRenderModule mod_custom () (2.43KB) (0.04%) | 178μs |
| 1 x Before Access::getAssetRules (id:4042 name:com_content.article.3392) (131.17KB) (0.03%) | 129μs |
| 1 x afterRenderModule mod_syndicate (Feed RSS) (2.52KB) (0.02%) | 112μs |
| 1 x afterRenderModule mod_menu () (10.27KB) (0.02%) | 103μs |
| 1 x afterRenderModule mod_custom (Parkinsonews) (1.25KB) (0.02%) | 95μs |
| 1 x After Access::getAssetRules (id:8 name:com_content) (7.73KB) (0.01%) | 53μs |
| 1 x After Access::getAssetRules (id:1 name:root.1) (7.73KB) (0.01%) | 42μs |
| 4 x beforeRenderModule mod_custom () (704B) (0.01%) | 38μs |
| 4 x beforeRenderModule mod_menu () (696B) (0.01%) | 36μs |
| 1 x Before Access::preloadPermissions (com_content) (4.74KB) (0.01%) | 31μs |
| 1 x beforeRenderRawModule mod_custom () (9.23KB) (0.01%) | 23μs |
| 1 x beforeRenderModule mod_related_items (Notizie correlate) (720B) (0%) | 14μs |
| 1 x beforeRenderModule mod_menu (Footer Menu) (720B) (0%) | 14μs |
| 1 x beforeRenderModule mod_syndicate (Feed RSS) (720B) (0%) | 12μs |
| 1 x beforeRenderModule mod_custom (Parkinsonews) (720B) (0%) | 10μs |
SELECT @@SESSION.sql_mode;138μs1.61KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334CopySELECT `data`
FROM `jml_session`
WHERE `session_id` = ?200μs1.63KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261CopySELECT `session_id`
FROM `jml_session`
WHERE `session_id` = :session_id LIMIT 1189μs1.63KBParams/libraries/src/Session/MetadataManager.php:187CopyINSERT INTO `jml_session`
(`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES
(:session_id, :guest, :time, :user_id, :username, :client_id)7.88ms976BParams/libraries/src/Session/MetadataManager.php:260CopySELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled`
FROM `jml_extensions`
WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1501μs21.39KB/libraries/src/Component/ComponentHelper.php:399CopySELECT `id`,`rules`
FROM `jml_viewlevels`169μs1.22KB/libraries/src/Access/Access.php:955CopySELECT `b`.`id`
FROM `jml_usergroups` AS `a`
LEFT JOIN `jml_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt`
WHERE `a`.`id` = :guest210μs1.7KBParams/libraries/src/Access/Access.php:868CopySELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id`
FROM `jml_extensions`
WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2)
ORDER BY `ordering`1.46ms16.84KBParams/libraries/src/Plugin/PluginHelper.php:294CopySELECT *
FROM `jml_languages`
WHERE `published` = 1
ORDER BY `ordering` ASC306μs4.05KB/libraries/src/Language/LanguageHelper.php:142CopySELECT `element`,`name`,`client_id`,`extension_id`
FROM `jml_extensions`
WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1253μs1.48KB/libraries/src/Language/LanguageHelper.php:213CopySELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component`
FROM `jml_menu` AS `m`
LEFT JOIN `jml_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id`
WHERE
(
(`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND
(`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND
(`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2)
ORDER BY `m`.`lft`2.87ms203.69KBParams/libraries/src/Menu/SiteMenu.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`497μs6.84KBParams/libraries/src/Categories/Categories.php:375CopySELECT `id`
FROM `jml_content`
WHERE `alias` = :alias AND `catid` = :catid240μs1.7KBParams/components/com_content/src/Service/Router.php:263CopySELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent`
FROM `jml_template_styles` AS `s`
LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id`
WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1351μs17.4KB/administrator/components/com_templates/src/Model/StyleModel.php:773CopySHOW TABLES1.1ms8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678CopySELECT `id`,`name`,`rules`,`parent_id`
FROM `jml_assets`
WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44)692μs11.41KBParams/libraries/src/Access/Access.php:357CopySELECT `id`,`name`,`rules`,`parent_id`
FROM `jml_assets`
WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 03.95ms444.34KBParams/libraries/src/Access/Access.php:301CopySHOW FULL COLUMNS FROM `jml_content`444μs10.48KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625CopyUPDATE `jml_content`
SET `hits` = (`hits` + 1)
WHERE `id` = '3392'8.41ms56B/libraries/src/Table/Table.php:1325CopySELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count`
FROM `jml_content` AS `a`
INNER JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid`
LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id`
LEFT JOIN `jml_users` AS `u` ON `u`.`id` = `a`.`created_by`
LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id`
LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id`
WHERE
(
(`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND
(`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)514μs9.72KBParams/components/com_content/src/Model/ArticleModel.php:215CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`615μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `m`.`tag_id`,`t`.*
FROM `jml_contentitem_tag_map` AS `m`
INNER JOIN `jml_tags` AS `t` ON `m`.`tag_id` = `t`.`id`
WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)298μs5.5KBParams/libraries/src/Helper/TagsHelper.php:388CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`648μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
FROM jml_fields AS a
LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language
LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access
LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id
LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
LEFT JOIN `jml_fields_categories` AS fc ON fc.field_id = a.id
WHERE
(
(`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND
(`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND
(`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform
ORDER BY a.ordering ASC869μs6.37KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`708μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT custom_data FROM jml_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1326μs64.88KB/templates/yootheme/packages/platform-joomla/src/Storage.php:30CopySELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid`
FROM `jml_modules` AS `m`
LEFT JOIN `jml_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id`
LEFT JOIN `jml_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id`
WHERE
(
(
(`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND
(`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND
(`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4)
ORDER BY `m`.`position`,`m`.`ordering`2.97ms132.25KBParams/libraries/src/Cache/Controller/CallbackController.php:51CopySELECT `metakey`
FROM `jml_content`
WHERE `id` = :id205μs1.67KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:88CopySELECT `a`.`id`
FROM `jml_content` AS `a`
WHERE
(
(
(`a`.`id` != :id AND `a`.`state` = 1 AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`metakey` LIKE :preparedArray3 OR `a`.`metakey` LIKE :preparedArray4 OR `a`.`metakey` LIKE :preparedArray5 OR `a`.`metakey` LIKE :preparedArray6 OR `a`.`metakey` LIKE :preparedArray7)) AND
(`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :nowDate1)) AND
(`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray8,:preparedArray9) LIMIT 20641μs3.34KBParams/modules/mod_related_items/src/Helper/RelatedItemsHelper.php:152CopySELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count`
FROM `jml_content` AS `a`
LEFT JOIN `jml_categories` AS `c` ON `c`.`id` = `a`.`catid`
LEFT JOIN `jml_users` AS `ua` ON `ua`.`id` = `a`.`created_by`
LEFT JOIN `jml_users` AS `uam` ON `uam`.`id` = `a`.`modified_by`
LEFT JOIN `jml_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id`
LEFT JOIN `jml_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id`
LEFT JOIN `jml_content_rating` AS `v` ON `a`.`id` = `v`.`content_id`
WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`id` IN (:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown)
ORDER BY a.ordering ASC2.84ms332.03KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`602μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`451μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`416μs17.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`408μs6.38KBParams/libraries/src/Categories/Categories.php:375CopySELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`
FROM `jml_categories` AS `s`
INNER JOIN `jml_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`)
WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id
ORDER BY `c`.`lft`444μs6.9KBParams/libraries/src/Categories/Categories.php:375CopySELECT `params`
FROM `jml_comprofiler_plugin`
WHERE `id` = 1221μs896BCopySELECT `id`
FROM `jml_rstbox`
WHERE `published` = 1 AND `testmode` = 0155μs928B/administrator/components/com_rstbox/EngageBox/Boxes.php:45CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 3162μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 3 AND `visitorid` = '1bf78c6db67470ca' AND MONTH(date) = 03 AND YEAR(date) = 2025186μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT *
FROM `jml_rstbox`
WHERE `id` = 5144μs2.23KB/administrator/components/com_rstbox/EngageBox/Box.php:238CopySELECT COUNT(id)
FROM `jml_rstbox_logs`
WHERE `event` = 1 AND `box` = 5 AND `visitorid` = '1bf78c6db67470ca'167μs896B/administrator/components/com_rstbox/EngageBox/Assignments.php:201CopySELECT `language`,`id`
FROM `jml_menu`
WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0485μs976B/libraries/src/Language/Multilanguage.php:123CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id151μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `alias`
FROM `jml_content`
WHERE `id` = :id142μs1.67KBParams/components/com_content/src/Service/Router.php:168CopySELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid`
FROM `jml_content` AS `c`
INNER JOIN `jml_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context
INNER JOIN `jml_associations` AS `a2` ON `a`.`key` = `a2`.`key`
INNER JOIN `jml_content` AS `c2` ON `a2`.`id` = `c2`.`id`
INNER JOIN `jml_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2
WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'it-IT' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-25 06:51:09') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-25 06:51:09') AND c2.state = 1369μs1.81KBParams/libraries/src/Language/Associations.php:145CopySELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note
FROM jml_fields AS a
LEFT JOIN `jml_languages` AS l ON l.lang_code = a.language
LEFT JOIN jml_users AS uc ON uc.id=a.checked_out
LEFT JOIN jml_viewlevels AS ag ON ag.id = a.access
LEFT JOIN jml_users AS ua ON ua.id = a.created_user_id
LEFT JOIN jml_fields_groups AS g ON g.id = a.group_id
WHERE
(
(`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND
(`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND
(`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform
ORDER BY a.ordering ASC585μs5.63KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166CopySELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count
FROM `jml_scheduler_tasks` AS `a`
WHERE `a`.`state` = 1213μs1.75KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:517CopySHOW TABLES793μs8.83KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:678CopySELECT `session_id`
FROM `jml_session`
WHERE `session_id` = ?126μs1.67KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291CopyUPDATE `jml_session`
SET `data` = ?
, `time` = ?
WHERE `session_id` = ?7.28ms936BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy